Hello!
I’m Karthiga
I am an oncologist specializing in drug discovery with a focus on combating cancer cell invasion. Throughout my career, I have pioneered innovative approaches to study and target invasive mechanisms in brain tumours, developing advanced 3D in vitro tumour models that accurately replicate tumour environments. Using these models, I have created high-throughput screening methods to identify novel therapeutic targets. By combining my expertise in oncology with advanced skills in Computer-Assisted Drug Design (CADD), I developed F2i, a novel and patented inhibitor with 85% efficacy against FGFR-driven cancers, marking a breakthrough in targeting invasive cancer pathways.
Upcoming Research
Novel 3D tumouroid models for precision modelling of cancer cell invasion in vitro
Current 3D models, though valuable, fall short in replicating the complexity of the tumor microenvironment (TME). To overcome these limitations, we propose a multi-faceted model incorporating synthetic ECM analogs with tailored control over stiffness and composition to mimic the native extracellular matrix (ECM).
Unlocking Cancer’s Secrets: Machine Learning-Powered Quantification of Cell Invasion and Discovery of Novel Targets
Traditional methods for studying cancer invasion are limited in their ability to process and analyse large, complex datasets. By integrating advanced machine learning algorithms with high-content imaging of 3D cancer models,
